39736-28-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-2-methylthiothiazole-5-carbonitrile is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a building block for the development of new drug molecules, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
4-AMINO-2-METHYLTHIOTHIAZOLE-5-CARBONITRILE is also utilized as an intermediate in the synthesis of agrochemicals, playing a role in the development of products for agricultural applications.
Used in Medicinal Chemistry Research:
4-Amino-2-methylthiothiazole-5-carbonitrile is used as a research compound in medicinal chemistry. Its potential as a building block for drug synthesis makes it valuable for exploring new therapeutic agents and enhancing the understanding of molecular interactions.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Amino-2-methylthiothiazole-5-carbonitrile is used for the synthesis of organic molecules with biological activity. Its unique properties enable the creation of new compounds with potential applications in various industries.
Used in Antimicrobial and Anti-tumor Research:
4-Amino-2-methylthiothiazole-5-carbonitrile has been studied for its antimicrobial and anti-tumor properties, making it a compound of interest in the development of new therapeutic agents. Its potential in these areas highlights its importance in the ongoing search for effective treatments and preventative measures against infections and cancer.

Upstream product

• 10191-61-4 potassium S-methyl N-cyanocarbamodithioate 
• 107-14-2 chloroacetonitrile 
• 82060-31-9 C₃H₆N₄O₂S₂ 
• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 
• 10191-68-1 C₅H₅N₃S₂ 

Downstream Products

• 120891-11-4 4-chloro-2-(methylsulfanyl)-1,3-thiazole-5-carbonitrile 
• 1361961-48-9 5-(difluoro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-(methylsulfinyl)thiazolo[4,5-d]pyrimidin-7-amine 
• 1361961-46-7 5-(difluoro-(4-fluorophenyl)methyl)-2-(methylthio)thiazolo[4,5-d]pyrimidin-7(6H)-one 
• 1361961-47-8 7-chloro-5-(difluoro-(4-fluorophenyl)methyl)-2-(methylthio)thiazolo[4,5-d]pyrimidine 
• 1361960-75-9 5-(difluoro-(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-(methylthio)thiazolo[4,5-d]pyrimidin-7-amine 
• 39736-30-6 4-amino-2-(methylsulfanyl)-1,3-thiazole-5-carboxamide 
• 119011-56-2 7-Chlor-2-(methylthio)thiazolo<4,5-d>pyrimidin 

Relevant academic research and scientific papers

NOVEL BICYCLIC HETEROCYCLIC COMPOUND

Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.

4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K+-ATPase and Ras oncogene activity in cancer cells

The in vitro growth inhibitory activity of 26 thiazoles (including 4-halogeno-2,5-disubtituted-1,3-thiazoles) and 5 thienothiazoles was assessed on a panel of 6 human cancer cell lines, including glioma cell lines. (4-Chloro-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12a) and (4-bromo-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12b) displayed ～10 times greater in vitro growth inhibitory activity than perillyl alcohol (POH), which therapeutically benefits glioma patients through the inhibition of both alpha-1 Na+/K+-ATPase (NAK) and Ras oncogene activity. The in vitro cytostatic activities (as revealed by quantitative videomicroscopy) displayed by 12a and 12b were independent of the intrinsic resistance to pro-apoptotic stimuli associated with cancer cells. Compounds 12a and 12b displayed relatively similar inhibitory activities on purified guinea pig brain preparations that mainly express NAK alpha-2 and alpha-3 subunits, whereas only compound 12b was efficacious against purified guinea pig kidney preparations that mainly express the NAK alpha-1 subunit, which is also expressed in gliomas, melanomas and non-small-cell lung cancers NSCLCs.

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

2,7-Diamino-thiazolo[4,5-d]pyrimidine analogues were synthesized as novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Representative compounds showed potent and selective EGFR inhibitory activities and inhibited in vitro cellular p

Synthesis of substituted [1,3]thiazolo[4,5-b]pyridines and [1,3]thiazolo[4,5-d][1,2,3]triazines

In this work, we described an easy preparation of substituted 4-amino-5-cyano-1,3-thiazoles. These compounds have been used as starting materials to obtain two classes of compounds. New substituted [1,3]thiazolo[4,5-e]pyridines were synthesized in one step via Friedl?nder reaction. Diazotation of 4-amino-5-cyano-1,3-thiazoles afforded 4-chloro[1,3]thiazolo[4,5-d][1,2,3]triazines in one step. The later was substituted by a secondary amine to obtain substituted 4-amino[1,3]thiazolo[4,5-d][1,2,3]triazines.

THIAZOLOPYRIMIDINE KINASE INHIBITORS

The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof, and the use thereof as inhibitors of ATP-protein kinase interactions.

New thiazole compounds having fungicidal activity

The invention relates to new thiazole compounds of the general formula STR1 wherein R is an C1 -C12 alkyl group or a phenyl group, which groups are unsubstituted or substituted with halogen, nitro or cyano; R1 is a cyano group; a formyl group; an alkylcarbonyl or alkoxycarbonyl group having 2-5 carbon atoms; or a substituted or non-substituted benzoyl group; R2 is a hydrogen atom; a halogen atom; an amino group; an amino group substituted with 1 or 2 substituents selected from the group consisting of C1 -C4 alkyl, C2 -C5 alkynyl, C2 -C5 alkylcarbonyl and C2 -C5 alkoxycarbonyl; an alkyl, alkoxy, alkylthio, alkylsulphinyl or alkyl-sulphonyl group having 1-4 carbon atoms; or a substituted or non-substituted aryl, aryloxy, arylthio, arylsulphinyl or arylsulphonyl group; and n is 1 or 2. The new compounds show a fungicidal activity and may be used in particular against plant pathogenic seed fungi and soil fungi.

A New Synthesis of Substituted 4-Amino-1,3-thiazoles

In the 5-position substituted 4-amino-2-alkylthio-1,3-thiazoles are prepared in good yields from N-nitro-amidino-dithiocarbamates 1 and α-halogen-carbonylcompounds or chloracetonitrile. 1 reacts with 1,3-dichlor-acetone under formation of adequate bis(1,3