(S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

Base Information

Chemical Name:(S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid
CAS No.:1620084-03-8
Molecular Formula:C₃₀H₃₃N₃O₄
Molecular Weight:499.61
Hs Code.:

Synonyms:(S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

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Chemical Property of (S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

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Technology Process of (S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

There total 10 articles about (S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₄₉N₃O₈

: 1620084-03-8
(S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

Guidance literature:: With trifluoroacetic acid; for 0.333333h;

Reference yield:

: 1198570-69-2
tert-butyl 2-bromo-3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate

: 1620084-03-8
(S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 125 °C

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

3: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 60 °C

4: trifluoroacetic acid / 0.33 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1620084-00-5
(S)-tert-butyl 3-(3-allylphenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylcarbamate

: 1620084-03-8
(S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 125 °C

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

3: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 60 °C

4: trifluoroacetic acid / 0.33 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;