(4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

Base Information

Chemical Name:(4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate
CAS No.:1620083-87-5
Molecular Formula:C₂HF₃O₂*C₃₀H₃₁N₃O₃
Molecular Weight:595.618
Hs Code.:

(4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

Synonyms:(4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

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Chemical Property of (4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

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Technology Process of (4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

There total 11 articles about (4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620084-03-8
(S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid

: 76-05-1
trifluoroacetic acid

: 1620083-87-5
(4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

Guidance literature:: (S)-2-(2-(3-(3-(2-amino-3-((4-methoxyphenyl)(methyl)amino)-3-oxopropyl)phenyl)propyl)-1H-indol-3-yl)acetic acid; With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1198570-69-2
tert-butyl 2-bromo-3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate

: 1620083-87-5
(4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 125 °C

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

3: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 60 °C

4: trifluoroacetic acid / 0.33 h

5: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1620084-00-5
(S)-tert-butyl 3-(3-allylphenyl)-1-((4-methoxyphenyl)(methyl)amino)-1-oxopropan-2-ylcarbamate

: 1620083-87-5
(4S)-N-(4-methoxyphenyl)-N-methyl-2-oxo-2,3,4,5,1,1,12,13,14-octahydro-1H-6,10-(metheno)azacyclopentadecino[5,4-b]indole-4-carboxamide trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 125 °C

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

3: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 60 °C

4: trifluoroacetic acid / 0.33 h

5: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;