rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester

Base Information

• Chemical Name: rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester
• CAS No.: 1031207-95-0
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 1031207-95-0.mol

Synonyms:rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester

Chemical Property of rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester

There total 3 articles about rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

rac-4-acetyl-4-methyl-2-phenyloxazol-5-one (17153-02-5) + isopropyl alcohol (67-63-0,8013-70-5) → rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester (1031207-95-0)

Guidance literature:

With dmap; at 20 ℃; for 16h;

DOI:10.1055/s-2008-1032104

Reference yield:

5-acetyloxy-4-methyl-2-phenyloxazole (17153-00-3) → rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester (1031207-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 3 h / 20 °C

2: dmap / 16 h

With dmap; In dichloromethane; 1: Steglich Rearrangement;

DOI:10.1055/s-0029-1217140

Reference yield:

2-phenyl-4-methyl-4H-oxazolin-5-one (51127-13-0,71963-72-9,87480-74-8,13302-43-7) → rac-2-benzoylamino-2-methyl-3-oxobutyric acid isopropyl ester (1031207-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1.17 h / 0 °C

2: dmap / dichloromethane / 3 h / 20 °C

3: dmap / 16 h

With dmap; triethylamine; In tetrahydrofuran; dichloromethane; 2: Steglich Rearrangement;

DOI:10.1055/s-0029-1217140

upstream raw materials:

rac-4-acetyl-4-methyl-2-phenyloxazol-5-one

isopropyl alcohol

5-acetyloxy-4-methyl-2-phenyloxazole

2-phenyl-4-methyl-4H-oxazolin-5-one