C₄₈H₉₅IO₄Si₄

Base Information

• Chemical Name: C₄₈H₉₅IO₄Si₄
• CAS No.: 1297531-53-3
• Molecular Formula: C₄₈H₉₅IO₄Si₄
• Molecular Weight: 975.526
• Mol file: 1297531-53-3.mol

Synonyms:C₄₈H₉₅IO₄Si₄

Chemical Property of C₄₈H₉₅IO₄Si₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₉₅IO₄Si₄

There total 14 articles about C₄₈H₉₅IO₄Si₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4S,8S,9S,E)-9-(3,5-bis((triisopropylsilyl)oxy)phenyl)-2,4,8-trimethyl-5,9-bis((triethylsilyl)oxy)non-6-en-1-ol (1297531-47-5) → C48H95IO4Si4 (1297531-53-3)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; acetonitrile; at 20 ℃; Darkness;

DOI:10.1021/ol200834p

Reference yield:

tert-butyl(((2S,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)oxy)diphenylsilane (1297531-62-4) → C48H95IO4Si4 (1297531-53-3)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: C₅H₅N*HO₃S; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3: chromium dichloride; nickel dichloride / tetrahydrofuran; dimethyl sulfoxide / 17 h / 20 °C / Inert atmosphere; Large scale reaction

4: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

5: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 °C

6: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 20 °C / Darkness

With 1H-imidazole; 2,6-dimethylpyridine; chromium dichloride; C₅H₅N*HO₃S; tetrabutyl ammonium fluoride; water; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile; 3: Nozaki-Hiyama-Kishi reaction;

DOI:10.1021/ol200834p

Reference yield:

(2S,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentan-1-ol (765915-18-2) → C48H95IO4Si4 (1297531-53-3)

Guidance literature:

Multi-step reaction with 5 steps

1: C₅H₅N*HO₃S; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: chromium dichloride; nickel dichloride / tetrahydrofuran; dimethyl sulfoxide / 17 h / 20 °C / Inert atmosphere; Large scale reaction

3: 2,6-dimethylpyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

4: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 °C

5: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 20 °C / Darkness

With 1H-imidazole; 2,6-dimethylpyridine; chromium dichloride; C₅H₅N*HO₃S; water; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile; 2: Nozaki-Hiyama-Kishi reaction;

DOI:10.1021/ol200834p

upstream raw materials:

(2S,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentan-1-ol

tert-butyl(((2S,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)oxy)diphenylsilane

(2S,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanal

(S)-3-((S,E)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-2-enoyl)-isopropyloxazolidin-2-one

Downstream raw materials:

(8S,9S,E)-9-(3,5-bis((triisopropylsilyl)oxy)phenyl)-5-((2S,4S,Z)-6-cyclohexyl-4-methylhex-5-en-2-yl)-3,3,11,11-tetraethyl-8-methyl-4,10-dioxa-3,11-disilatridec-6-ene

(1S,2S,3E,6S,8S,9Z)-1-(3,5-bis((triisopropylsilyl)oxy)phenyl)-10-cyclohexyl-2,6,8-trimethyldeca-3,9-diene-1,5-diol

(1S,2S,6S,8S,Z)-1-(3,5-bis((triisopropylsilyl)oxy)phenyl)-10-cyclohexyl-1-hydroxy-2,6,8-trimethyldec-9-en-5-one

(2R,5S,6S)-6-(3,5-bis((triisopropylsilyl)oxy)phenyl)-2-((2S,4S,Z)-6-cyclohexyl-4-methylhex-5-en-2-yl)-5-methyltetrahydro-2H-pyran-2-ol