1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Base Information

Chemical Name:1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
CAS No.:144822-48-0
Molecular Formula:C31H31FN2O7
Molecular Weight:562.595
Hs Code.:
Mol file:144822-48-0.mol

Synonyms:1-[(3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-3-fluoro-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione;1-{5-O-[Bis-(4-methoxyphenyl)-phenylmethyl]-2-deoxy-2-fluoro--D-arabinofuranosyl}-5-methyl-2,4(1H,3H)-pyrimidinedione;

Suppliers and Price of 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine
250 mg
$ 172.50

Biosynth Carbosynth
1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine
100 mg
$ 92.50

Biosynth Carbosynth
1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine
50 mg
$ 50.00

AK Scientific
1-[(3S,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
250mg
$ 282.00

Total 9 raw suppliers

Chemical Property of 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

Chemical Property:

Refractive Index:1.639
PKA:9.55±0.10(Predicted)
PSA：112.01000
Density:1.36 g/cm³
LogP:3.46730

Purity/Quality:

99.3% ^*data from raw suppliers

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

There total 6 articles about 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 69256-17-3,163252-36-6,2923-73-1
1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine

: 144822-48-0,133324-02-4
5′-O-(dimethoxytrityl)-2′-β-fluorothymidine

Guidance literature:: With pyridine; at 20 ℃; for 2h;

Reference yield:

: 97614-44-3
2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide

: 144822-48-0,133324-02-4
5′-O-(dimethoxytrityl)-2′-β-fluorothymidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrachloromethane / 48 h / 80 °C

2: methylamine / ethanol / 3 h / 20 °C

3: pyridine / 2 h / 20 °C

With pyridine; methylamine; In tetrachloromethane; ethanol;

Reference yield:

: 7288-28-0
2,4-bis(trimethylsiloxy)-5-methylpyrimidine

: 144822-48-0,133324-02-4
5′-O-(dimethoxytrityl)-2′-β-fluorothymidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrachloromethane / 48 h / 80 °C

2: methylamine / ethanol / 3 h / 20 °C

3: pyridine / 2 h / 20 °C

With pyridine; methylamine; In tetrachloromethane; ethanol;