C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine

Base Information

• Chemical Name: C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine
• CAS No.: 861390-01-4
• Molecular Formula: C₁₉H₂₉Cl₂N₃
• Molecular Weight: 370.365

Synonyms:C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine

Chemical Property of C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine

Chemical Property:

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Technology Process of C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine

There total 4 articles about C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-ylmethyl]-carbamic acid tert-butyl ester (861390-37-6) → C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine (861390-01-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2005.04.054

Reference yield:

piperidin-4-one (41661-47-6) → C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine (861390-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 65 percent / Et₃N / 1,2-dichloro-ethane / Heating

2.1: Ti(OiPr)4; Et₂AlCN / CH₂Cl₂

2.2: 88 percent / tetrahydrofuran / 0 °C

3.1: 100 percent / TFA / CH₂Cl₂

With titanium(IV) isopropylate; diethylaluminium cyanide; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2005.04.054

Reference yield:

3,4-Dichlorophenylmethyl chloride (102-47-6) → C-[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-yl]-methylamine (861390-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 65 percent / Et₃N / 1,2-dichloro-ethane / Heating

2.1: Ti(OiPr)4; Et₂AlCN / CH₂Cl₂

2.2: 88 percent / tetrahydrofuran / 0 °C

3.1: 100 percent / TFA / CH₂Cl₂

With titanium(IV) isopropylate; diethylaluminium cyanide; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2005.04.054

upstream raw materials:

[1'-(3,4-dichloro-benzyl)-4'-methyl-[1,4']bipiperidinyl-3-ylmethyl]-carbamic acid tert-butyl ester

piperidin-4-one

3,4-Dichlorophenylmethyl chloride

1-(3,4-dichlorobenzyl)-4-piperidone

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