tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate
• CAS No.: 1104443-04-0
• Molecular Formula: C₂₂H₂₈N₂O₆S
• Molecular Weight: 448.54
• Mol file: 1104443-04-0.mol

Synonyms:tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate

There total 6 articles about tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

4-hydroxy-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (1104442-05-8) + 3-methanesulfonyloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (141699-56-1) → tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate (1104443-04-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 140 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm501175v

Reference yield:

4-(benzyloxy)pyridin-2(1H)-one (53937-02-3) → tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate (1104443-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 4 h / 145 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1.5 h / 760.05 Torr / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 4 h / 140 °C / Inert atmosphere

With copper(l) iodide; 8-quinolinol; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;

DOI:10.1021/jm501175v

Reference yield:

4-bromoohenyl methyl sulfone (3466-32-8) → tert-butyl 3-(((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate (1104443-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 4 h / 145 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1.5 h / 760.05 Torr / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 4 h / 140 °C / Inert atmosphere

With copper(l) iodide; 8-quinolinol; palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;

DOI:10.1021/jm501175v

upstream raw materials:

4-(benzyloxy)pyridin-2(1H)-one

4-bromoohenyl methyl sulfone

4-(benzyloxy)-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one

4-hydroxy-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one