Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester

Base Information

• Chemical Name: Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester
• CAS No.: 122663-93-8
• Molecular Formula: C₁₈H₂₂O₄S
• Molecular Weight: 334.436
• Mol file: 122663-93-8.mol

Synonyms:Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester

Chemical Property of Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester

There total 3 articles about Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(phenylthio)hept-2-yn-4-ol (122663-89-2) + ethyl chlorocarbonylacetate (36239-09-5) → Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester (122663-93-8)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(01)85601-5

Reference yield:

phenyl propargyl sulfide (5651-88-7) → Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester (122663-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) ethylmagnesium bromide / 2.) THF, 0 deg C

2: 96 percent / pyridine / tetrahydrofuran / 3 h / 0 °C

With pyridine; ethylmagnesium bromide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)99523-6

Reference yield:

thiophenol (108-98-5) → Malonic acid ethyl ester 4-phenylsulfanyl-1-propyl-but-2-ynyl ester (122663-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / aq. NaOH, 10percent Bu₄NF / benzene / a) 0 deg C, 30 min, b) r.t., 2h

2: 1) EtMgBr / 1) THF, 0 deg C, 1h, 2) 0 deg C, 1.5h

3: 96 percent / pyridine / tetrahydrofuran / 2 h / 0 °C

With pyridine; sodium hydroxide; ethylmagnesium bromide; tetrabutyl ammonium fluoride; In tetrahydrofuran; benzene;

DOI:10.1016/S0040-4020(01)85601-5

upstream raw materials:

1-(phenylthio)hept-2-yn-4-ol

ethyl chlorocarbonylacetate

phenyl propargyl sulfide

thiophenol

Downstream raw materials:

2-Diazo-malonic acid ethyl ester (Z)-(S)-4-phenylsulfanyl-1-propyl-but-2-enyl ester

(3S,4R,5R)-2-Oxo-3-phenylsulfanyl-5-propyl-4-vinyl-tetrahydro-furan-3-carboxylic acid ethyl ester

Malonic acid ethyl ester (Z)-4-phenylsulfanyl-1-propyl-but-2-enyl ester