(3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

Base Information

Chemical Name:(3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid
CAS No.:1297553-62-8
Molecular Formula:C₁₁H₉ClF₄O₂
Molecular Weight:284.638
Hs Code.:

Synonyms:(3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

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Chemical Property of (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

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Technology Process of (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

There total 4 articles about (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.7%

: 1297551-89-3
ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate

: 1297553-62-8
(3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

Guidance literature:: ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 0 - 20 ℃;

With hydrogenchloride; In water; pH=~ 2;

Reference yield:

: 835629-56-6
(3R)-4,4,4-trifluoro-3-methylbutanoic acid

: 1297553-62-8
(3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / 80 °C

2.1: lithium hexamethyldisilazane / toluene / -20 °C

2.2: -20 - 80 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0 - 20 °C

3.2: pH ~ 2

With thionyl chloride; water; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 1297549-70-2
(+)-ethyl (3R)-4,4,4-trifluoro-3-methylbutanoate

: 1297553-62-8
(3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / toluene / -20 °C

1.2: -20 - 80 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0 - 20 °C

2.2: pH ~ 2

With water; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;