ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate

Base Information

Chemical Name:ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate
CAS No.:1297551-89-3
Molecular Formula:C₁₃H₁₃ClF₄O₂
Molecular Weight:312.692
Hs Code.:

Synonyms:ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate

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Technology Process of ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate

There total 3 articles about ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.1%

: 1996-29-8
1-bromo-4-chloro-2-fluorobenzene

: 1297549-70-2
(+)-ethyl (3R)-4,4,4-trifluoro-3-methylbutanoate

: 1297551-89-3
ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate

Guidance literature:: (+)-ethyl (3R)-4,4,4-trifluoro-3-methylbutanoate; With lithium hexamethyldisilazane; In toluene; at -20 ℃;

1-bromo-4-chloro-2-fluorobenzene; palladium diacetate; DavePhos; In toluene; at -20 - 80 ℃;

Reference yield:

: 835629-56-6
(3R)-4,4,4-trifluoro-3-methylbutanoic acid

: 1297551-89-3
ethyl (3R)-2-(4-chloro-2-fluorophenyl)-4,4,4-trifluoro-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / 80 °C

2.1: lithium hexamethyldisilazane / toluene / -20 °C

2.2: -20 - 80 °C

With thionyl chloride; lithium hexamethyldisilazane; In toluene;