2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester

Base Information

Chemical Name:2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester
CAS No.:206655-68-7
Molecular Formula:C₂₆H₃₀N₄O₄
Molecular Weight:462.549
Hs Code.:

Synonyms:2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester

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Chemical Property of 2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester

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Technology Process of 2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester

There total 7 articles about 2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 207562-22-9
2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carbonyl chloride

: 100-51-6,185532-71-2
benzyl alcohol

: 206655-68-7
2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1248/cpb.46.591

Reference yield:

: 7154-34-9
2,4-diamino-6-nitroquinazoline

: 206655-68-7
2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂, AcOH / 10percent Pd/C / dimethylformamide / 3 h / 3102.9 Torr

2: 1.) aq. NaNO₂, aq. HCl, 2.) aq. CuSO₄ / 1.) 0 deg C, 2.) 55 deg C, 30 min

3: 93 percent / 70percent aq. HCO₂H, Ni-Al alloy / 1.25 h / Heating

4: 82 percent / dimethylformamide / 60 h / 80 °C

5: 98 percent / aq. NaClO₂, NaH₂PO₄*H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol

6: 100 percent / oxalyl chloride / toluene / 1.5 h / 40 °C

7: 56 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; aluminum nickel; hydrogen; copper(II) sulfate; acetic acid; triethylamine; sodium nitrite; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1248/cpb.46.591

Reference yield:

: 27023-77-4
2,4-diamino-quinazoline-6-carboxaldehyde

: 206655-68-7
2,4-Bis-(2,2-dimethyl-propionylamino)-quinazoline-6-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / dimethylformamide / 60 h / 80 °C

2: 98 percent / aq. NaClO₂, NaH₂PO₄*H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol

3: 100 percent / oxalyl chloride / toluene / 1.5 h / 40 °C

4: 56 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1248/cpb.46.591