2,4-DIAMINO-6-NITROQUINAZOLINE

Base Information

• Chemical Name: 2,4-DIAMINO-6-NITROQUINAZOLINE
• CAS No.: 7154-34-9
• Molecular Formula: C8H7N5O2
• Molecular Weight: 205.17
• Hs Code.: 2933990090
• Mol file: 7154-34-9.mol

Synonyms:Quinazoline,2,4-diamino-6-nitro- (8CI);NSC 73515;6-Nitroquinazoline-2,4-diamine;2,4-Diamino-6-nitroquinazoline;6-Nitro-2,4-quinazolinediamine;

Chemical Property of 2,4-DIAMINO-6-NITROQUINAZOLINE

Chemical Property:

• Vapor Pressure: 1.32E-12mmHg at 25°C
• Melting Point: >360°C
• Refractive Index: 1.825
• Boiling Point: 560.8 °C at 760 mmHg
• Flash Point: 293 °C
• PSA: 123.64000
• Density: 1.623 g/cm³
• LogP: 2.38800

Purity/Quality:

99% ^*data from raw suppliers

2,4-Diamino-6-nitroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIAMINO-6-NITROQUINAZOLINE

There total 7 articles about 2,4-DIAMINO-6-NITROQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-nitroanthranilonitrile (17420-30-3) + guanidine hydrochloride (50-01-1) → 2,4-diamino-6-nitroquinazoline (7154-34-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 13h; Inert atmosphere;

Reference yield: 85.0%

5-nitroanthranilonitrile (17420-30-3) + guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) → 2,4-diamino-6-nitroquinazoline (7154-34-9)

Guidance literature:

With potassium hydroxide; In propan-1-ol; ethanol; at 90 ℃; for 6h;

DOI:10.1007/s00044-018-2188-7

Reference yield: 85.0%

5-nitroanthranilonitrile (17420-30-3) + diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) → 2,4-diamino-6-nitroquinazoline (7154-34-9)

Guidance literature:

With sodium methylate; In methanol; at 100 ℃; for 0.25h; under 11251.1 Torr; Microwave irradiation;

DOI:10.1016/j.bmcl.2008.10.129

upstream raw materials:

5-nitroanthranilonitrile

guanidine nitrate

guanidine hydrogen carbonate

diguanidine carbonate

Downstream raw materials:

2-amino-6-nitro-3H-quinazolin-4-one

2,4-diamino-6-azidoquinazoline

N⁶-(4-methoxy-benzylidene)-quinazoline-2,4,6-triamine

Refernces

• 1、 Matus-Meza, Audifás S.,Velasco-Velázquez, Marco A.,Hernández-Luis, Francisco. "Design, synthesis and cytotoxic evaluation of quinazoline-2,4,6-triamine and 2,6-diaminoquinazolin-4(3H)-one derivatives". . p. 1748 - 1756. Retrieved 2018/05/26.
• 2、 Chen, Wenhua,Huang, Zhenghui,Wang, Wanyan,Mao, Fei,Guan, Longfei,Tang, Yun,Jiang, Hualiang,Li, Jian,Huang, Jin,Jiang, Lubin,Zhu, Jin. "Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely". . p. 6467 - 6478. Retrieved 2017/10/31.