methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate

Base Information

• Chemical Name: methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate
• CAS No.: 1395283-91-6
• Molecular Formula: C₂₁H₂₂F₃NO₄
• Molecular Weight: 409.405
• Mol file: 1395283-91-6.mol

Synonyms:methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate

Chemical Property of methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate

There total 5 articles about methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

→ methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate (1395283-91-6)

Guidance literature:

Reference yield:

2-bromo-3-fluoro-6-methylpyridine (374633-36-0) → methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate (1395283-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium permanganate / water

2: sulfuric acid / methanol

With potassium permanganate; sulfuric acid; In methanol; water;

Reference yield:

2-(3,5-difluorophenyl)-2-methyl-propanoic acid (879904-44-6) → methyl 6-(4-(1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)-2,6-difluorophenyl)-5-fluoropicolinate (1395283-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: n-butyllithium

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;

upstream raw materials:

2-(3,5-difluorophenyl)-2-methyl-propanoic acid

2-bromo-3-fluoro-6-methylpyridine

6-bromo-5-fluoro-pyridine-2-carboxylic acid

tert-butyl 2-(3,5-difluorophenyl)-2-methylpropanoate