4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Base Information

• Chemical Name: 4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide
• CAS No.: 1345417-82-4
• Molecular Formula: C₃₈H₄₁N₇O₄
• Molecular Weight: 659.788
• Mol file: 1345417-82-4.mol

Synonyms:4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Chemical Property of 4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

There total 8 articles about 4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(E)-2-(3-quinolinyl)-ethenyl]benzoic acid (1000277-46-2) + C20H30N6O3 → 4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide (1345417-82-4)

Guidance literature:

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.08.035

Reference yield:

Ethyl 4-nitropyrrole-2-carboxylate (5930-92-7) → 4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide (1345417-82-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

1.2: 5 h / 100 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol; water / 2 h / Reflux

2.2: 0 °C

3.1: thionyl chloride / 3 h / Reflux

4.1: 4-methyl-morpholine / dichloromethane / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C / Inert atmosphere

6.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With 4-methyl-morpholine; thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.08.035

Reference yield:

4-{[(1-isopropyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide (1345417-70-0) → 4-({[1-isopropyl-4-({4-[(E)-2-(3-quinolinyl)ethenyl]benzoyl}amino)-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide (1345417-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 0 °C / Inert atmosphere

2: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.08.035

upstream raw materials:

4-[(E)-2-(3-quinolinyl)-ethenyl]benzoic acid

4-{[(1-isopropyl-4-nitro-1H-pyrrol-2-yl)carbonyl]amino}-1-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide

Ethyl 4-nitropyrrole-2-carboxylate

4-amino-1-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide