5,6,7,8-Tetrahydroquinolin-8-amine

Base Information

• Chemical Name: 5,6,7,8-Tetrahydroquinolin-8-amine
• CAS No.: 298181-83-6
• Molecular Formula: C9H12N2
• Molecular Weight: 148.208
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID80463255
• Nikkaji Number: J1.962.076J
• Mol file: 298181-83-6.mol

Synonyms:8-amino-5,6,7,8-tetrahydroquinoline

Chemical Property of 5,6,7,8-Tetrahydroquinolin-8-amine

Chemical Property:

• Vapor Pressure: 0.00456mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 277.3 °C at 760 mmHg
• PKA: 8.93±0.20(Predicted)
• Flash Point: 146 °C
• PSA: 38.91000
• Density: 1.081 g/cm³
• LogP: 2.11800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 148.100048391
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

5,6,7,8-tetrahydroquinolin-8-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C2=C(C1)C=CC=N2)N

Technology Process of 5,6,7,8-Tetrahydroquinolin-8-amine

There total 11 articles about 5,6,7,8-Tetrahydroquinolin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6,7-dihydro-5H-quinolin-8-one oxime (58509-59-4) → 5,6,7,8-tetrahydroquinolin-8-yl amine (298181-83-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 18h; under 2585.81 Torr;

Reference yield: 92.0%

5,6,7,8-tetrahydro-8-quinolinone (56826-69-8) → 5,6,7,8-tetrahydroquinolin-8-yl amine (298181-83-6)

Guidance literature:

With palladium on activated charcoal; ammonia; hydrogen; In methanol; at 20 ℃; for 12h;

Reference yield: 90.0%

8-azido-5,6,7,8-tetrahydroquinoline (1374781-10-8) → 5,6,7,8-tetrahydroquinolin-8-yl amine (298181-83-6)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/open.201900222

upstream raw materials:

(R)-(-)-8-amino-5,6,7,8-tetrahydroquinoline

6,7-dihydro-5H-quinolin-8-one oxime

5,6,7,8-tetrahydroquinoline

(R)-N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide

Downstream raw materials:

C₂₂H₂₂N₄O

N-(2-nitrobenzenesulfonyl)-N-(2-pyridinylmethyl)-N'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine

3-[(5,6,7,8-tetrahydroquinolin-8-ylamino)methyl]benzonitrile

4-[(5,6,7,8-tetrahydroquinolin-8-ylamino)methyl]benzonitrile