4-Hydroxy-2-oxo-1-pyrrolidineacetic acid

Base Information

• Chemical Name: 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid
• CAS No.: 77191-37-8
• Molecular Formula: C6H9NO4
• Molecular Weight: 159.142
• Hs Code.: 2933790090
• Mol file: 77191-37-8.mol

Synonyms:4-Hydroxy-2-oxo-1-pyrrolidineaceticacid;

Chemical Property of 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• Boiling Point: 465.565 °C at 760 mmHg
• PKA: 3.75±0.10(Predicted)
• Flash Point: 235.365 °C
• PSA: 77.84000
• Density: 1.509 g/cm³
• LogP: -1.39790
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Hydroxy-2-oxopyrrolidin-1-yl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Oxiracetam 1-Pyrrolidineacetic acid is a derivative of Oxiracetam(O846905) a nootropic. Analog of Piracetam with psychostimulant activity.

Technology Process of 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid

There total 10 articles about 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

oxiracetam (68252-28-8,68567-97-5,88929-35-5,62613-82-5) → 4-hydroxy-2-oxo-1-pyrrolidine acetic acid (77191-37-8,99437-11-3)

Guidance literature:

With lithium hydroxide monohydrate; at 55 - 60 ℃; for 24h; Reagent/catalyst; Temperature;

Reference yield: 80.0%

ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate (62613-81-4) → 4-hydroxy-2-oxo-1-pyrrolidine acetic acid (77191-37-8,99437-11-3)

Guidance literature:

With sodium hydroxide; In water; for 3h; Ambient temperature;

Reference yield: 60.0%

→ 4-hydroxy-2-oxo-1-pyrrolidine acetic acid (77191-37-8,99437-11-3)

Guidance literature:

upstream raw materials:

1-ethoxycarbonylmethylpyrrolidine-2,4-dione

ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate

2,4-dioxopyrrolidin-1-yl-acetic acid

(2,4-dioxopyrrolidin-1-yl)acetamide hydrochloride

Downstream raw materials:

ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate

((S)-4-hydroxy-2-oxopyrrolidin-1-yl)acetic acid

Refernces

• 1、 -. "Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide". . . Retrieved 2008/06/13.
• 2、 Banfi,Fonio,Allievi,Pinza,Dorigotti. "Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.". . p. 16 - 22. Retrieved 2007/10/02.