62613-81-4

Basic information

• Product Name: ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate
• Synonyms: ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate;4-Hydroxy-2-oxo-1-pyrrolidineacetic acid ethyl ester;oxiracetaM related substance;ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetate;OxiracetaM iMpurity D;Oxiracetam IMP
• CAS NO: 62613-81-4
• Molecular Formula: C₈H₁₃NO₄
• Molecular Weight: 187.19312
• EINECS: 263-640-1
• Mol File: 62613-81-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 367°C at 760 mmHg
• Flash Point: 175.8°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 7.07E-07mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: 2-8°C
• PKA: 13.70±0.20(Predicted)
• CAS DataBase Reference: ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate(62613-81-4)
• EPA Substance Registry System: ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate(62613-81-4)

Safety Data

• Hazardous Substances Data: 62613-81-4(Hazardous Substances Data)

Usage

Uses

4-Hydroxy-2-oxo-1-pyrrolidineacetic Acid Ethyl Ester is an impurity of the nootropic Oxiracetam (O846905).

InChI:InChI=1/C8H13NO4/c1-2-13-8(12)5-9-4-6(10)3-7(9)11/h6,10H,2-5H2,1H3

Upstream product

• 68252-20-0 4-Trimethylsilyloxy-1H-pyrrolidin-2one 
• 105-36-2 ethyl bromoacetate 
• 62613-80-3 1-ethoxycarbonylmethylpyrrolidine-2,4-dione 
• 7664-93-9 sulfuric acid 
• 77191-37-8 4-hydroxy-2-oxo-1-pyrrolidine acetic acid 
• 110104-61-5 ethyl (2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)acetate 
• 110853-09-3 ethyl (4-methoxy-2-oxopyrrolidin-1-yl)acetate 

Downstream Products

• 77191-37-8 4-hydroxy-2-oxo-1-pyrrolidine acetic acid 
• 68252-28-8 oxiracetam 
• 120428-80-0 N-(2-amino-2-oxoethyl)-2-(4-hydroxy-2-oxotetrahydropyrrol-1-yl)acetamide 

Relevant articles and documents

Oxiracetam preparation method

An oxiracetam preparation method comprises the following steps: (a) azidation reaction of 4-chloro-3-hydroxybutyrate as a starting material and an azidation reagent to obtain an give intermediate I; (2) reduction reaction of the intermediate I to obtain an intermediate II; (2) condensation reaction of the intermediate II and a halogenated acetic acid ester to obtain an intermediate III; (3) ring closing reaction of the intermediate III to obtain an intermediate IV; and (4) aminolysis reaction of the intermediate IV to obtain desired product oxiracetam. The desired product oxiracetam with an ideal yield of at least more than 38% can be obtained, and a new oxiracetam synthetic route is opened up.

An efficient synthesis of racemic 4-hydroxy-2-oxo-1-pyrrolidineacetamide (oxiracetam) using tetramic-acid intermediates

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Cyclic GABA-GABOB analogues. III. Synthesis and biochemical activity of new alkyl and acyl derivatives of 4-hydroxy-2-pyrrolidinone

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