(5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine

Base Information

Chemical Name:(5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine
CAS No.:1151513-47-1
Molecular Formula:C₂₀H₁₇N₇O
Molecular Weight:371.401
Hs Code.:

Synonyms:(5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine

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Chemical Property of (5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine

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Technology Process of (5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine

There total 2 articles about (5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1151513-23-3
tert-butyl N-[[5-[1-[(4-pyrazol-1-ylphenyl)methyl]indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]carbamate

: 1151513-47-1
(5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In water; at 20 ℃; for 18h;
DOI:10.1021/jm801180p

Reference yield:

: 1151512-98-9
3-[3-tert-butoxycarbonylaminomethyl-1,2,4-oxadiazol-5-yl]indazole

: 1151513-47-1
(5-(1-(4-(1H-pyrazol-1-yl)benzyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; chlorotriisopropylsilane; water / 18 h / 20 °C

With chlorotriisopropylsilane; water; caesium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm401881q