3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide

Base Information

Chemical Name:3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide
CAS No.:1455029-04-5
Molecular Formula:C₁₉H₁₇F₇N₄O
Molecular Weight:450.359
Hs Code.:

Synonyms:3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide

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Chemical Property of 3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide

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Technology Process of 3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide

There total 4 articles about 3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.6%

: 41463-83-6
3,3,3-trifluoropropanoyl chloride

: 1455029-02-3
N-(((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)-2-hydrazinyl-3-(trifluoromethyl)pyridin-4-amine

: 1455029-04-5
3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; ethyl acetate; for 0.166667h;

Reference yield:

: 1186194-98-8
2,4-dichloro-3-(trifluoromethyl)pyridine

: 1455029-04-5
3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrogenchloride / acetonitrile; water / 6 h / Reflux; Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

3: sodium carbonate / water; tetrahydrofuran; ethyl acetate / 0.17 h

With hydrogenchloride; sodium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1455582-66-7,372184-05-9
((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methanamine

: 1455029-04-5
3,3,3-trifluoro-N'-(4-((((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)amino)-3-(trifluoromethyl)pyridin-2-yl)propanehydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrogenchloride / acetonitrile; water / 6 h / Reflux; Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

3: sodium carbonate / water; tetrahydrofuran; ethyl acetate / 0.17 h

With hydrogenchloride; sodium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile;