1186194-98-8

Basic information

• Product Name: 2,4-Dichloro-3-(trifluoromethyl)pyridine
• Synonyms: 2,4-Dichloro-3-(trifluoromethyl)pyridine;2,4-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline
• CAS NO: 1186194-98-8
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.9879896
• Mol File: 1186194-98-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: oil°
• Boiling Point: 220.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.542±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.46±0.10(Predicted)
• CAS DataBase Reference: 2,4-Dichloro-3-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-3-(trifluoromethyl)pyridine(1186194-98-8)
• EPA Substance Registry System: 2,4-Dichloro-3-(trifluoromethyl)pyridine(1186194-98-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1186194-98-8(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-3-(trifluoromethyl)pyridine is an organic compound composed of a pyridine ring substituted with two chlorine atoms, a trifluoromethyl group, and a hydrogen atom. The pyridine ring acts as the primary structural feature of the compound, featuring nitrogen as one of six constituent atoms. 2,4-Dichloro-3-(trifluoromethyl)pyridine falls under the category of halopyridines, which are compounds containing a pyridine ring where one or more carbon atoms are replaced by a halogen. The compound is of interest in chemical research and development due to its potential for various chemical reactions. It is used as an intermediate in the synthesis of agrochemicals and pharmaceuticals.

InChI:InChI=1S/C6H2Cl2F3N/c7-3-1-2-12-5(8)4(3)6(9,10)11/h1-2H

Upstream product

• 343781-36-2 2,4-dichloro-3-iodo-pyridine 
• 26452-80-2 2,4-dichloropyridine 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 

Downstream Products

• 1254981-27-5 4-(benzyloxy)-2-chloro-3-(trifluoromethyl)pyridine 
• 1254981-34-4 2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl 
• 1254981-31-1 2'-chloro-4-fluoro-4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl 
• 1254981-28-6 4-(benzyloxy)-2-hydrazineyl-3-(trifluoromethyl)pyridine 
• 1254981-29-7 N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide 
• 1376334-38-1 3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)-1-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine 
• 1163693-02-4 2-chloro-4-methoxy-3-(trifluoromethyl)pyridine 

Relevant articles and documents

INHIBITOR OF BTK AND MUTANTS THEREOF

The disclosure includes compounds of Formula (I) (1) wherein Q0, Q1, Q2, Q3, Q4, Z, W, i, j, m, n, Warhead, R0, R1, R3, R4, R5, R6, and R7, are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel 1,2,4-triazolo[4,3-a]pyridine compounds of Formula (I) as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of mGluR2 subtype disorders.

1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.