L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester

Base Information

• Chemical Name: L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester
• CAS No.: 3268-81-3
• Molecular Formula: C₂₀H₂₈N₆O₇
• Molecular Weight: 464.478
• DSSTox Substance ID: DTXSID401115335

Synonyms:DTXSID401115335;3268-81-3;L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester

Chemical Property of L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 12
• Exact Mass: 464.20194725
• Heavy Atom Count: 33
• Complexity: 720

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CCCN1C(=O)C(CCCN=C(N)N[N+](=O)[O-])NC(=O)OCC2=CC=CC=C2
• Isomeric SMILES: COC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])NC(=O)OCC2=CC=CC=C2

Technology Process of L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester

There total 3 articles about L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithine (2304-98-5) + L-proline methyl ester monohydrochloride (2133-40-6) → Nα-Benzyloxycarbonyl-NG-nitro-L-arginyl-L-proline Methyl Ester (3268-81-3)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1) 2.5h, 0 deg C, 2) 17h, RT;

Reference yield:

N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithine (2304-98-5) + methyl (2S)-pyrrolidine carboxylate (2577-48-2) → Nα-Benzyloxycarbonyl-NG-nitro-L-arginyl-L-proline Methyl Ester (3268-81-3)

Guidance literature:

With 4-methyl-morpholine; chloroformic acid ethyl ester; Multistep reaction; 1) THF, 2) DMF, r.t.;

DOI:10.1246/bcsj.64.1533

Reference yield:

→ Z-Arg(NO2)-PrOMe (3268-81-3)

Guidance literature:

N-NO2Arg-Z, PrOMe-Hydrochlorid;

upstream raw materials:

N₅-[imino(nitroamino)methyl]-N₂-[(phenylmethoxy)carbonyl]-L-ornithine

L-proline methyl ester monohydrochloride

methyl (2S)-pyrrolidine carboxylate

Downstream raw materials:

Z-Arg(NO₂)-Pro-OH

N^α-Benzyloxycarbonyl-L-leucyl-N^G-nitro-L-arginyl-L-proline

N^α-Benzyloxycarbonyl-L-leucyl-N^G-nitro-L-arginyl-L-proline Methyl Ester

N^α-Benzyloxycarbonyl-L-leucyl-N^G-nitro-L-arginyl-L-prolylglycinamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 3268-81-3 N^α-Benzyloxycarbonyl-N^G-nitro-L-arginyl-L-proline Methyl Ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send