2304-98-5

Basic information

• Product Name: Z-ARG(NO2)-OH
• Synonyms: Cbz-L-Arg(NO2)-OH;N-Benzyloxycarbonyl-N-nitro-L-arginine;N2-BENZYLOXYCARBONYL-NG-NITRO-L-ARGININE;Z-(NITRO)-ARGININE;N-alpha-Benzyloxycarbonyl-N-nitro-L-arginine;N-.ALPHA.-CBZ-N-.OMEGA.-NITRO-L-ARGININE;Nalpha-carbobenzyloxy-Nomega-nitro-L-arginine;N5-[Imino(nitroamino)methyl]-N2-[(benzyloxy)carbonyl]-L-ornithine
• CAS NO: 2304-98-5
• Molecular Formula: C₁₄H₁₉N₅O₆
• Molecular Weight: 353.33
• EINECS: 218-970-0
• Product Categories: Cbz-Amino acid series
• Mol File: 2304-98-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 130-132 °C (dec.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /Solid
• Density: 1.44g/cm³
• Refractive Index: 1.615
• Storage Temp.: 2-8°C
• Solubility: Methanol (Sparingly)
• PKA: 3.84±0.50(Predicted)
• CAS DataBase Reference: Z-ARG(NO2)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-ARG(NO2)-OH(2304-98-5)
• EPA Substance Registry System: Z-ARG(NO2)-OH(2304-98-5)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 2304-98-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Z-Arg(NO2)-OH, is a building block used in peptide chemistry.

InChI:InChI=1/C14H19N5O6/c15-13(18-19(23)24)16-8-4-7-11(12(20)21)17-14(22)25-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,17,22)(H,20,21)(H3,15,16,18)

Upstream product

• 2149-70-4 N^ω-nitro-L-arginine 
• 501-53-1 benzyl chloroformate 
• 1119-34-2 L-arginine hydrochloride 
• 2149-70-4 N-nitro-L-arginine 
• 74-79-3 L-arginine 

Downstream Products

• 111033-46-6 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-Ξ-serine ethyl ester 
• 120793-33-1 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-Ξ-serine benzyl ester 
• 16652-69-0 Z-Arg(NO₂)-Gly-OEt 
• 24127-10-4 N^α-benzyloxycarbonyl-N^G-nitroarginylglycine benzyl ester 
• 13850-69-6 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-alanine methyl ester 
• 10433-54-2 N^α-benzyloxycarbonyl-N^ω-nitro-L-arginine amide 
• 5085-27-8 Z-Arg(Z)-Gly-OMe 
• 74863-20-0 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-tyrosine methyl ester 
• 2270-24-8 1-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-Ξ-proline 
• 106386-18-9 α-Carbobenzoxy-ω-nitro-L-arginyl-ω-carbobenzoxy-L-lysin-methylester 
• 21844-71-3 N^α-benzyloxycarbonyl-N^ε-nitro-L-arginine 4-picolyl ester 
• 140135-28-0 C₂₆H₃₄N₆O₅ 
• 21466-91-1 N^α-benzyloxycarbonyl-N^G-nitroarginylglycine p-nitrobenzyl ester 
• 102249-04-7 N^α-benzyloxycarbonyl-N^G-nitroarginyl(O-benzyl)serine methyl ester 

Relevant articles and documents

Improved selective protections of L-arginine

Reliable procedures for the selective introduction of carbobenzyloxy and phthalimido groups onto the α-amino position, and of carboethoxy groups onto the δ- and ω-guanidino positions of L-arginine are described.

Isolation and characterization of Nα-Benzyloxycarbonyl amino Acid Urethane Hydrolase II from Lactobacillus fermenti 36 ATCC 9338

A novel enzyme, which was named Nα-benzloxycarbonyl amino acid urethane hydrolase II, was purified from a cell-free extract of Lactobacillus fermenti 36ATCC 9338.The enzyme catalyzed the stoichiometric hydrplysis of N-α-benzyloxycarbonyl arginine to form benzyl alcohol and arginine.The enzyme was purified 106-fold with an activity yield of 3percent.The purified enzyme was homogeneous by disc gel electrophoresis.The molecular weight of native enzyme is about 200,000 by gel filtration, and a molecular weight of 27,000 was found for the reduced and denaturated enzyme was 5.0, it was inhibited by disodium ethylenediamine tetraacetate and p-chloromercuribenzoate, and the presence of a divalent cation, i.e.Co2+, is essential for its activity.