(E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid

Base Information

Chemical Name:(E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid
CAS No.:1440434-23-0
Molecular Formula:C₂₁H₂₀N₂O₇
Molecular Weight:412.399
Hs Code.:

Synonyms:(E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid

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Chemical Property of (E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid

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Technology Process of (E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid

There total 7 articles about (E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1440434-30-9
C₂₇H₂₈N₂O₉

: 1440434-23-0
(E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid

Guidance literature:: With methanol; sodium hydroxide; In water; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmcl.2013.04.033

Reference yield:

: 331-39-5,501-16-6
caffeic acid

: 1440434-23-0
(E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 5 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / Cooling with ice

3: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

4: methanol; sodium hydroxide / water / 0.25 h / 20 °C

With pyridine; methanol; oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2013.04.033

Reference yield:

: 88623-81-8
3,4-diacetoxycinnamic acid

: 1440434-23-0
(E)-2-(2-(cyclopropanecarboxamido)-4-(3-(3,4-dihydroxyphenyl)acrylamido)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / Cooling with ice

2: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

3: methanol; sodium hydroxide / water / 0.25 h / 20 °C

With methanol; oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2013.04.033