10.3987/COM-10-S(E)102
The research aimed to synthesize antioxidant flavonoid derivatives, specifically quercetin-caffeic acid and quercetin-curcumin conjugates, to prevent age-related macular degeneration (AMD). The study sought to enhance the antioxidative properties of the naturally occurring plant antioxidant quercetin by linking it with other plant antioxidants, caffeic acid and curcumin. The researchers designed and synthesized quercetin derivatives connected to these natural products via an appropriate linker, expecting the resulting compounds to have increased chemical stability and antioxidative activities. The study concluded with the successful synthesis of new types of antioxidants, quercetin/caffeic acid derivative 7 and quercetin/curcumin derivative 11, and planned to further compare their antioxidant properties with other known antioxidants, with ongoing studies on their activity against A2E photooxidation.
10.1016/j.ejmech.2019.111880
This study investigates the development of 13 new phenol-lipoyl hybrids (SV1-13) as potential anti-Alzheimer agents. The researchers synthesized these hybrids by combining phenolic acids, such as caffeic and ferulic acids, with lipoic acid using various linkers. The phenolic acids and lipoic acid contribute antioxidant and anti-amyloid properties to the hybrids, which are designed to interact with multiple targets involved in Alzheimer's disease progression. The study evaluates the physico-chemical properties, stability in simulated gastrointestinal fluids and human plasma, and biological activities of these hybrids. The results show that SV5, SV9, and SV10 significantly protect SH-SY5Y cells against Aβ1-42-induced neurotoxicity, with SV9 and SV10 demonstrating remarkable antioxidant properties. However, SV5 exhibits the highest stability in human plasma and the best overall pharmacological profile, making it a promising candidate for further development as a multifunctional anti-Alzheimer agent.