methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate

Base Information

Chemical Name:methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate
CAS No.:340757-00-8
Molecular Formula:C₃₁H₃₈N₄O₇S
Molecular Weight:610.731
Hs Code.:

Synonyms:methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate

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Chemical Property of methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate

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Technology Process of methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate

There total 5 articles about methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 340756-75-4
N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide

: 340809-44-1
methyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-phenylalaninate

: 340757-00-8
methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm000544b

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 340757-00-8
methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; N-methylmorpholine / CH₂Cl₂

2: 59 percent / NaBH(OAc)3; AcOH / dimethylformamide / 20 °C

With 4-methyl-morpholine; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000544b

Reference yield:

: 79421-38-8
4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid ethyl ester

: 340757-00-8
methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 2 N aq. NaOH / methanol; tetrahydrofuran / 2 h / Heating

2: 88 percent / aq. HCl / 15 h / 20 °C

3: 75 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; N-methylmorpholine / CH₂Cl₂

4: 59 percent / NaBH(OAc)3; AcOH / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000544b