79421-38-8

Usage

Uses

Used in Food and Beverage Industry:
Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester is used as a flavoring agent for its aromatic and fruity odor, enhancing the taste and aroma of various food and beverage products.
Used in Pharmaceutical Industry:
Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester is used in pharmaceuticals due to its potential antifungal and antimicrobial properties, making it a valuable compound in the development of medications and treatments.
Used in Cosmetic Industry:
Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester is used in cosmetics for its aromatic properties, contributing to the scent and overall sensory experience of cosmetic products.

Upstream product

• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 584-08-7 potassium carbonate 

Downstream Products

• 1022929-13-0 C₁₆H₂₃NO₄ 
• 1449429-06-4 ethyl 4-(2-amino-3-cyano-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate 
• 1449428-71-0 ethyl 4-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)benzoate 
• 340757-08-6 [butyl(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)ethylamino]piperidin-1-yl}benzoyl)amino]acetic acid ethyl ester 
• 340757-00-8 methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate 
• 340756-99-2 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate 
• 340756-98-1 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-valinate 
• 340756-97-0 methyl 1-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-prolinate 
• 340756-96-9 ethyl [(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)amino]acetate 
• 340756-95-8 dibenzyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-glutamate 
• 340756-91-4 3-[4-(4-oxopiperidin-1-yl)benzoylamino]propionic acid benzyl ester 

Relevant academic research and scientific papers

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

Peptidoglycan is an essential component of the bacterial cell wall, and enzymes involved in its biosynthesis represent validated targets for antibacterial drug discovery. MurF catalyzes the final intracellular peptidoglycan biosynthesis step: the addition of D-Ala-D-Ala to the nucleotide precursor UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP (or L-Lys). As MurF has no human counterpart, it represents an attractive target for the development of new antibacterial drugs. Using recently published cyanothiophene inhibitors of MurF from Streptococcus pneumoniae as a starting point, we designed and synthesized a series of structurally related derivatives and investigated their inhibition of MurF enzymes from different bacterial species. Systematic structural modifications of the parent compounds resulted in a series of nanomolar inhibitors of MurF from S. pneumoniae and micromolar inhibitors of MurF from Escherichia coli and Staphylococcus aureus. Some of the inhibitors also show antibacterial activity against S. pneumoniae R6. These findings, together with two new co-crystal structures, represent an excellent starting point for further optimization toward effective novel antibacterials.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

BCL-2 INHIBITORS

The present invention relates to Bcl-2 inhibitors and their use in the treatment of cell proliferative diseases such as cancer.

HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE

Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: wherein Q, V and W independently represent -N= or -C=; B is

N-acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

HETEROCYCLIC BETA-3 ADRENERGIC RECEPTOR AGONISTS

This invention provides compounds of Formula I having the structure U, V, W, X, and Y are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

2-Arylbenzo(b)(1,6)naphthyridines as inhibitors of interleukin 1

There is disclosed a method for the treatment of inflammatory conditions and of collegenase-induced tissue destruction which comprises the administration of a therapeutically effective amount of a compound of the formula STR1 wherein R1 is phen

Pyrazolo(4,3-c)quinolines

There are disclosed compounds of the formula STR1 wherein the various substituents are defined hereinbelow, and, by virtue of their ability to inhibit interleukin 1, their use as antiinflammatory agents and in treatment of disease states involving enzymat