5-Phenyl-2-morpholinone

Base Information

• Chemical Name: 5-Phenyl-2-morpholinone
• CAS No.: 134872-85-8
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.203
• Hs Code.: 2934999090
• Mol file: 134872-85-8.mol

Synonyms:5-phenylmorpholin-2-one;2-morpholinone, 5-phenyl-;5-Phenylmorpholin-2-on;R-5-Phenyl-morpholin-2-one;

Chemical Property of 5-Phenyl-2-morpholinone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 364.33 °C at 760 mmHg
• Flash Point: 174.141 °C
• PSA: 38.33000
• Density: 1.149 g/cm³
• LogP: 1.20290
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Phenylmorpholin-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Phenyl-2-morpholinone

There total 9 articles about 5-Phenyl-2-morpholinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(S)-5-phenylmorpholin-2-one hydrochloride (491833-36-4) → (5S)-5-phenylmorpholin-2-one (144896-92-4,134872-85-8)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; for 0.5h;

Reference yield: 86.0%

→ (5S)-5-phenylmorpholin-2-one (144896-92-4,134872-85-8)

Guidance literature:

Reference yield: 78.0%

phenyl 2-bromoacetate (620-72-4) + D-2-phenylglycinol (56613-80-0) → (R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one (121269-45-2,134872-85-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 18h; Ambient temperature;

DOI:10.1021/jo00277a032

upstream raw materials:

phenyl 2-bromoacetate

(2S)-2-phenylglycinol

(5S)-N-(benzyloxycarbonylaminomethyl)-5-phenylmorpholin-2-one

(S)-5-phenylmorpholin-2-one hydrochloride

Downstream raw materials:

(4S,6aS,9aR,9bS)-4-Phenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

(4S,6aR,9aS,9bS)-8-((S)-2-Oxo-5-phenyl-morpholin-4-ylmethyl)-4-phenyl-hexahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-c][1,4]oxazine-1,7,9-trione

2(R),6(R),7(S),8(R) 2-phenyl-1-aza-4-oxa<4.3.0^1,6>bicyclononan-5-one-7,8-dicarboximide

2(R),6(R),7(R),8(S)-N-<(5'(R)-phenylmorpholin-2-onyl)methyl>-2-phenyl-1-aza-4-oxa<4.3.0^1,6>bicyclononan-5-one-7,8-dicarboximide

Refernces

• 1、 -. "Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors". Page/Page column 16; 17. . Retrieved 2017/02/09.
• 2、 -. "IMPROVED PROCESS FOR THE PREPARATION OF ELIGLUSTAT AND ITS SALTS". Page/Page column 26. . Retrieved 2017/05/10.