(6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester
• CAS No.: 104163-93-1
• Molecular Formula: C₂₂H₂₇NO₈S
• Molecular Weight: 465.524

Synonyms:(6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Chemical Property of (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

There total 4 articles about (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(6R,7S)-3-Acetoxymethyl-8-oxo-7-phenethyloxy-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (127732-95-0) → (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ6-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (104163-93-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00171a028

Reference yield:

2-phenylethanol (60-12-8) → (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ6-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (104163-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 percent / tosic acid / CH₂Cl₂ / 0.67 h / 0 °C

2: 86 percent / m-chloroperbenzoic acid (m-CPBA) / CH₂Cl₂ / 2 h / Ambient temperature

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jm00171a028

Reference yield:

tert-butyl 3-(acetyloxymethyl)-7-diazo-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate (58249-92-6) → (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-phenethyloxy-5λ6-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (104163-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 percent / tosic acid / CH₂Cl₂ / 0.67 h / 0 °C

2: 86 percent / m-chloroperbenzoic acid (m-CPBA) / CH₂Cl₂ / 2 h / Ambient temperature

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jm00171a028

upstream raw materials:

(6R,7S)-3-Acetoxymethyl-8-oxo-7-phenethyloxy-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

2-phenylethanol

tert-butyl 3-(acetyloxymethyl)-7-diazo-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

7-Aminocephalosporanic acid t-butyl ester

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