N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide

Base Information

Chemical Name:N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide
CAS No.:1310412-64-6
Molecular Formula:C₂₁H₂₇F₂NO₂Si
Molecular Weight:391.533
Hs Code.:

Synonyms:N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide

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Technology Process of N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide

There total 2 articles about N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1310412-45-3
1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

: 66324-10-5
tert-butyldimethyl(1-phenylvinyloxy)silane

: 1310412-64-6
N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide

Guidance literature:: With 2,2'-azobis(isobutyronitrile); thiophenol; In benzene; at 80 ℃; for 18h; regioselective reaction; Inert atmosphere;
DOI:10.1002/asia.201000881

Reference yield:

: 244022-63-7
3,5-difluorobenzoic acid hydrazide

: 1310412-64-6
N-[2-(tert-butyldimethylsilanyloxy)-2-phenylethyl]-3,5-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 18 h / 20 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); thiophenol / benzene / 18 h / 80 °C / Inert atmosphere

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); thiophenol; In ethanol; water; benzene;
DOI:10.1002/asia.201000881