1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

Base Information

Chemical Name:1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
CAS No.:1310412-45-3
Molecular Formula:C₂₀H₂₂F₂N₂O₅
Molecular Weight:408.402
Hs Code.:

Synonyms:1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

Chemical Property:

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Technology Process of 1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

There total 2 articles about 1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 244022-63-7
3,5-difluorobenzoic acid hydrazide

: 67079-26-9
diethyl 2,4-diacetylpentanedioate

: 1310412-45-3
1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/asia.201000881

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1310412-45-3
1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylamine / 1.5 h / 55 °C

1.2: 1 h / 20 °C

2.1: hydrogenchloride / ethanol; water / 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; diethylamine; In ethanol; water;
DOI:10.1002/asia.201000881

Reference yield: 92.0%

: 926-02-3
tert-butyl vinyl ether

: 1310412-45-3
1-(3,5-difluorobenzoylamino)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

: 1310412-57-7
N-(2-tert-butoxyethyl)-3,5-difluorobenzamide

Guidance literature:: With 2,2'-azobis(isobutyronitrile); thiophenol; In benzene; at 80 ℃; for 18h; regioselective reaction; Inert atmosphere;
DOI:10.1002/asia.201000881