2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide

Base Information

Chemical Name:2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide
CAS No.:1416899-92-7
Molecular Formula:C₂₁H₁₂Cl₃F₇N₄O
Molecular Weight:575.7
Hs Code.:

Synonyms:2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide

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Chemical Property of 2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide

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Technology Process of 2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide

There total 7 articles about 2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₆Cl₄F₇N₃O

: 765-30-0
Cyclopropylamine

: 1416899-92-7
2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide

Guidance literature:: C₁₈H₆Cl₄F₇N₃O; Cyclopropylamine; With pyridine; In tetrahydrofuran; at 20 - 90 ℃;

With pyridine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In tetrahydrofuran; at 90 ℃; for 4h;

Reference yield:

: 273735-64-1
2,6-dichloro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]aniline

: 1416899-92-7
2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water; tert-butyl alcohol / 0.5 h / 20 °C

1.2: 1.5 h / 0 - 5 °C

1.3: 20 °C

2.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 96 h

3.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 50 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 50 °C / Inert atmosphere

5.1: pyridine / tetrahydrofuran / 20 - 90 °C

5.2: 4 h / 90 °C

With pyridine; hydrogenchloride; copper(ll) sulfate pentahydrate; oxalyl dichloride; water; sodium L-ascorbate; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 251085-87-7
methyl 5-bromo-2-chloro-benzoate

: 1416899-92-7
2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / triphenylphosphine; palladium diacetate / Inert atmosphere; Reflux

2.1: potassium carbonate; methanol / tetrahydrofuran / 1 h

3.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 96 h

4.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 50 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 50 °C / Inert atmosphere

6.1: pyridine / tetrahydrofuran / 20 - 90 °C

6.2: 4 h / 90 °C

With pyridine; methanol; copper(ll) sulfate pentahydrate; oxalyl dichloride; water; potassium carbonate; sodium L-ascorbate; triethylamine; lithium hydroxide; palladium diacetate; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;