(3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione

Base Information

• Chemical Name: (3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione
• CAS No.: 164736-93-0
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.24
• Mol file: 164736-93-0.mol

Synonyms:(3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione

Chemical Property of (3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione

There total 1 articles about (3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

L-Tartaric acid (87-69-4,138508-61-9) + phenethylamine (64-04-0) → (3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione (164736-93-0)

Guidance literature:

In xylene; for 3h; Heating;

DOI:10.1080/00397919508015871

Reference yield: 52.0%

(3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione (164736-93-0) → (3R,4R)-3,4,5-trihydroxy-1-(2-phenylethyl)-2-pyrrolidinone

Guidance literature:

With sodium tetrahydroborate; In ethanol; at -5 ℃;

DOI:10.1080/00397919508015871

Reference yield:

(3R,4R)-3,4-dihydroxy-1-(2-phenylethyl)-2,5-pyrrolidinedione (164736-93-0) → (3R,4R)-3,4-diacetoxy-5-ethoxy-1-(2-phenylethyl)-2-pyrrolidinone

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaBH₄, 2.) 1N ethanolic H₂SO₄ / 1.) EtOH, -5 deg C, 2.) RT, 12 h

2: 100 percent / Et₃N, DMAP / CH₂Cl₂ / 20 h / Ambient temperature

With dmap; sodium tetrahydroborate; sulfuric acid; triethylamine; In dichloromethane;

DOI:10.1080/00397919508015871

upstream raw materials:

L-Tartaric acid

phenethylamine

Downstream raw materials:

(1S,2R,10bS)-1,2-dihydroxy-1,2,3,5,6,10bβ-hexahydropyrrolo<2,1-a>isoquinolin-3(2H)-one