methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate

Base Information

Chemical Name:methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate
CAS No.:1188445-89-7
Molecular Formula:C₁₃H₉ClF₃NO₃
Molecular Weight:319.668
Hs Code.:

Synonyms:methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate

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Chemical Property of methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate

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Technology Process of methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate

There total 4 articles about methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188445-88-6
2-chloro-N-hydroxy-4-(trifluoromethyl)benzimidoyl chloride

: 105-45-3
acetoacetic acid methyl ester

: 1188445-89-7
methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate

Guidance literature:: With sodium hydride; In methanol; mineral oil; at -5 ℃; for 0.5h;

Reference yield:

: 82096-91-1
2-chloro-4-(trifluoromethyl)-benzaldehyde

: 1188445-89-7
methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 1 h / 25 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 25 °C

3: sodium hydride / methanol; mineral oil / 0.5 h / -5 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium hydride; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1188445-87-5
2-chloro-4-(trifluoromethyl)benzaldehyde oxime

: 1188445-89-7
methyl 3-(2-chloro-4-(trifluoromethyl)phenyl)-5-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 25 °C

2: sodium hydride / methanol; mineral oil / 0.5 h / -5 °C

With N-chloro-succinimide; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;