N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

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Chemical Name:N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide
CAS No.:484685-92-9
Molecular Formula:C₄₃H₅₁N₅O₆
Molecular Weight:733.908
Hs Code.:

Synonyms:N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

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Chemical Property of N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

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Technology Process of N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

There total 3 articles about N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 484685-82-7
N-[4-tert-butyloxy-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

: 484685-92-9
N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

Guidance literature:: N-[4-tert-butyloxy-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide; With trifluoroacetic acid; at 5 ℃; for 3h;

O-benzylhydoxylamine hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at -15 - 20 ℃;
DOI:10.1016/S0968-0896(02)00109-8

Reference yield:

: {2-[4-(benzyloxycarbonylamino-imino-methyl)-phenyl]-1-methylcarbamoyl-ethyl}-carbamic acid tert-butyl ester

: 484685-92-9
N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / ethyl acetate

1.2: 18 percent / 1-hydroxybenzotriazol; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / -15 - 20 °C

2.1: aqueous trifluoroacetic acid / 3 h / 5 °C

2.2: 38 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; triethylamine / dimethylformamide / -15 - 20 °C

With hydrogenchloride; trifluoroacetic acid; In ethyl acetate;
DOI:10.1016/S0968-0896(02)00109-8

Reference yield:

: 2-isobutyl-3-(3-phenyl-propyl)-succinic acid 4-tert-butyl ester; compound with tert-butylamine

: 484685-92-9
N-[4-(N-benzyloxyamino)-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N-(benzyloxycarbonyl)amidino]phenylalanine N-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / ethyl acetate

1.2: 18 percent / 1-hydroxybenzotriazol; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / -15 - 20 °C

2.1: aqueous trifluoroacetic acid / 3 h / 5 °C

2.2: 38 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; triethylamine / dimethylformamide / -15 - 20 °C

With hydrogenchloride; trifluoroacetic acid; In ethyl acetate;
DOI:10.1016/S0968-0896(02)00109-8