3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

Base Information

Chemical Name:3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate
CAS No.:1379461-36-5
Molecular Formula:C₁₉H₂₁ClF₃NO₆S
Molecular Weight:483.893
Hs Code.:

Synonyms:3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

Suppliers and Price of 3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

There total 6 articles about 3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888740-24-7
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propan-1-ol

: 124-63-0
methanesulfonyl chloride

: 1379461-36-5
3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

Guidance literature:: With triethylamine; In ethyl acetate; at 1 - 30 ℃; for 1h;

Reference yield:

: 888740-23-6
ethyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propanoate

: 1379461-36-5
3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.17 h / 0 °C

1.2: 0 °C

2.1: triethylamine / ethyl acetate / 1 h / 20 °C

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-62-3
ethyl (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(methoxymethoxy)phenyl]acrylate

: 1379461-36-5
3-[2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-(2-methoxyethoxy)phenyl]propyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

2.1: hydrogenchloride; water / tetrahydrofuran / 0.75 h / 50 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.17 h / 0 °C

4.2: 0 °C

5.1: triethylamine / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; tributylphosphine; palladium 10% on activated carbon; water; hydrogen; diisobutylaluminium hydride; triethylamine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethyl acetate; toluene; 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036