(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

Base Information

Chemical Name:(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide
CAS No.:1333115-34-6
Molecular Formula:C₂₉H₂₇N₃O₅S
Molecular Weight:529.616
Hs Code.:

Synonyms:(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

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Chemical Property of (R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

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Technology Process of (R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

There total 10 articles about (R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1333115-25-5
(R)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetic acid

: 613-89-8
2-Aminoacetophenone

: 1333115-34-6
(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

Guidance literature:: (R)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetic acid; With thionyl chloride; at 20 ℃; for 1h;

2-Aminoacetophenone; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1333115-34-6
(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 70 °C

2.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran; ethanol / 17 h / 20 °C / Inert atmosphere; Cooling with ice

5.1: phosphorus tribromide / tetrachloromethane / 2 h / 0 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: potassium carbonate / ethanol / 2 h / Reflux

8.1: triethylamine / dmap / dichloromethane / 20 °C

9.1: sodium periodate; water / ruthenium trichloride / tetrachloromethane; acetonitrile / 16 h / 20 °C

10.1: thionyl chloride / 1 h / 20 °C

10.2: 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; N-Bromosuccinimide; thionyl chloride; water; phosphorus tribromide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; calcium chloride; dmap; ruthenium trichloride; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 1333115-34-6
(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran; ethanol / 17 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: phosphorus tribromide / tetrachloromethane / 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: potassium carbonate / ethanol / 2 h / Reflux

6.1: triethylamine / dmap / dichloromethane / 20 °C

7.1: sodium periodate; water / ruthenium trichloride / tetrachloromethane; acetonitrile / 16 h / 20 °C

8.1: thionyl chloride / 1 h / 20 °C

8.2: 1 h / 20 °C

With sodium tetrahydroborate; sodium periodate; thionyl chloride; water; phosphorus tribromide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; calcium chloride; dmap; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile; mineral oil;