(R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Base Information

Chemical Name:(R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine
CAS No.:1333115-35-7
Molecular Formula:C₂₉H₂₆N₄O₃S
Molecular Weight:510.616
Hs Code.:

Synonyms:(R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

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Chemical Property of (R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

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Technology Process of (R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

There total 11 articles about (R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1333115-34-6
(R)-N-(2-oxo-2-phenylethyl)-2-(5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocin-4-yl)acetohvdrazide

: 1333115-35-7
(R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: With ammonium acetate; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Sealed; microwave irradiation;

Reference yield:

: 118-90-1
ortho-methylbenzoic acid

: 1333115-35-7
(R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: Multi-step reaction with 11 steps

1.1: hydrogenchloride / 70 °C

2.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran; ethanol / 17 h / 20 °C / Inert atmosphere; Cooling with ice

5.1: phosphorus tribromide / tetrachloromethane / 2 h / 0 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: potassium carbonate / ethanol / 2 h / Reflux

8.1: triethylamine / dmap / dichloromethane / 20 °C

9.1: sodium periodate; water / ruthenium trichloride / tetrachloromethane; acetonitrile / 16 h / 20 °C

10.1: thionyl chloride / 1 h / 20 °C

10.2: 1 h / 20 °C

11.1: ammonium acetate / N,N-dimethyl-formamide / 1 h / 150 °C / Sealed; microwave irradiation

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; N-Bromosuccinimide; thionyl chloride; ammonium acetate; water; phosphorus tribromide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; calcium chloride; dmap; ruthenium trichloride; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 1333115-35-7
(R)-4-((4-phenyl-1H-imidazol-2-yl)methyl)-5-(quinolin-8-ylsulfonyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium tetrahydroborate; calcium chloride / tetrahydrofuran; ethanol / 17 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: phosphorus tribromide / tetrachloromethane / 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: potassium carbonate / ethanol / 2 h / Reflux

6.1: triethylamine / dmap / dichloromethane / 20 °C

7.1: sodium periodate; water / ruthenium trichloride / tetrachloromethane; acetonitrile / 16 h / 20 °C

8.1: thionyl chloride / 1 h / 20 °C

8.2: 1 h / 20 °C

9.1: ammonium acetate / N,N-dimethyl-formamide / 1 h / 150 °C / Sealed; microwave irradiation

With sodium tetrahydroborate; sodium periodate; thionyl chloride; ammonium acetate; water; phosphorus tribromide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; calcium chloride; dmap; ruthenium trichloride; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;