oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester

Base Information

• Chemical Name: oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester
• CAS No.: 886990-17-6
• Molecular Formula: C₂₆H₃₆NO₁₀P
• Molecular Weight: 553.546

Synonyms:oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester

Chemical Property of oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester

Chemical Property:

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Technology Process of oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester

There total 3 articles about oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester (886990-15-4) + monomethyl oxalyl chloride (5781-53-3) → oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester (886990-17-6)

Guidance literature:

With dmap; In acetonitrile;

DOI:10.1016/j.bmcl.2005.05.016

Reference yield:

1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexanecarbaldehyde → oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester (886990-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / Et₃N

2: 87 percent / DMAP / acetonitrile

With dmap; triethylamine; In acetonitrile;

DOI:10.1016/j.bmcl.2005.05.016

Reference yield:

ethyl diethoxymethylphosphinate (65600-74-0) → oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester (886990-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / Et₃N

2: 87 percent / DMAP / acetonitrile

With dmap; triethylamine; In acetonitrile;

DOI:10.1016/j.bmcl.2005.05.016

upstream raw materials:

diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

monomethyl oxalyl chloride

ethyl diethoxymethylphosphinate

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