diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

Base Information

Chemical Name:diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester
CAS No.:886990-15-4
Molecular Formula:C₂₃H₃₄NO₇P
Molecular Weight:467.499
Hs Code.:

Synonyms:diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

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Chemical Property of diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

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Technology Process of diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

There total 1 articles about diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexanecarbaldehyde

: 65600-74-0
ethyl diethoxymethylphosphinate

: 886990-15-4
diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

Guidance literature:: With triethylamine;
DOI:10.1016/j.bmcl.2005.05.016

Reference yield: 87.0%

: 886990-15-4
diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

: 5781-53-3
monomethyl oxalyl chloride

: 886990-17-6
oxalic acid (diethoxymethyl-ethoxy-phosphinoyl)-[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-methyl ester methyl ester

Guidance literature:: With dmap; In acetonitrile;
DOI:10.1016/j.bmcl.2005.05.016

Reference yield:

: 886990-15-4
diethoxymethyl-{[1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-cyclohexyl]-hydroxy-methyl}-phosphinic acid ethyl ester

: (1-aminomethyl-cyclohexylmethyl)-phosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / DMAP / acetonitrile

2.1: Bu₃SnH; AIBN / toluene / Heating

2.2: aq. HCl / diethyl ether; dioxane

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; acetonitrile;
DOI:10.1016/j.bmcl.2005.05.016