methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

Base Information

• Chemical Name: methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate
• CAS No.: 1644120-86-4
• Molecular Formula: C₁₈H₁₇N₃O₂
• Molecular Weight: 307.352
• Mol file: 1644120-86-4.mol

Synonyms:methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

Chemical Property of methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

There total 6 articles about methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-Azido-3-phenylpropionsaeure-methylester (103999-80-0) + phenylacetylene (536-74-3) → methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate (1644120-86-4)

Guidance literature:

2-Azido-3-phenylpropionsaeure-methylester; With sodium azide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; sodium iodide; In dimethyl sulfoxide; at 10 - 60 ℃; for 2h;

phenylacetylene; With copper(ll) sulfate pentahydrate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In dimethyl sulfoxide; at 23 ℃; for 24h;

DOI:10.1002/anie.201402433

Reference yield:

benzyl bromide (100-39-0) → methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate (1644120-86-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 23 °C / Inert atmosphere

1.2: 2 h / 23 °C

2.1: potassium hydroxide / methanol / 4 h / 23 °C

3.1: iodine; sodium azide / dimethyl sulfoxide; water / 2 h / 60 °C

4.1: sodium iodide; sodium azide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate / dimethyl sulfoxide / 2 h / 10 - 60 °C

4.2: 24 h / 23 °C

With sodium azide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; iodine; sodium hydride; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;

DOI:10.1002/anie.201402433

Reference yield:

2-benzyl-malonic acid dimethyl ester (49769-78-0) → methyl 3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate (1644120-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / methanol / 4 h / 23 °C

2.1: iodine; sodium azide / dimethyl sulfoxide; water / 2 h / 60 °C

3.1: sodium iodide; sodium azide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate / dimethyl sulfoxide / 2 h / 10 - 60 °C

3.2: 24 h / 23 °C

With sodium azide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; iodine; sodium iodide; potassium hydroxide; In methanol; water; dimethyl sulfoxide;

DOI:10.1002/anie.201402433

upstream raw materials:

2-Azido-3-phenylpropionsaeure-methylester

phenylacetylene

2-benzyl-malonic acid dimethyl ester

C₁₂H₁₃IO₄