(2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

Base Information

Chemical Name:(2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone
CAS No.:1260505-22-3
Molecular Formula:C₂₃H₁₅BrF₂O₃
Molecular Weight:457.271
Hs Code.:

Synonyms:(2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

Chemical Property:

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Technology Process of (2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

There total 6 articles about (2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 103994-89-4
2-bromo-4,5-difluorobenzoyl chloride

: 19803-10-2
2-(4-methoxyphenyl)-5-methylbenzo[b]furan

: 1260505-22-3
(2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

Guidance literature:: With tin(IV) chloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.04.053

Reference yield:

: 106-44-5
p-cresol

: 1260505-22-3
(2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hypochlorite; sodium iodide; sodium hydroxide / methanol / 20 °C

2: pyridine / 2 h

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 6 h / 60 °C / Sealed tube

4: potassium carbonate / methanol / 60 °C

5: tin(IV) chloride / dichloromethane / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium hypochlorite; copper(l) iodide; tin(IV) chloride; potassium carbonate; triethylamine; sodium iodide; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; 3: Sonogashira coupling / 5: Friedel Crafts acylation;
DOI:10.1016/j.ejmech.2011.04.053

Reference yield:

: 1313886-73-5
2-((4-methoxyphenyl)ethynyl)-4-methylphenyl acetate

: 1260505-22-3
(2-bromo-4,5-difluorophenyl)(2-(4-methoxyphenyl)-5-methylbenzofuran-3-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 60 °C

2: tin(IV) chloride / dichloromethane / 20 °C

With tin(IV) chloride; potassium carbonate; In methanol; dichloromethane; 2: Friedel Crafts acylation;
DOI:10.1016/j.ejmech.2011.04.053