(R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate
CAS No.:1190115-60-6
Molecular Formula:C₃₇H₄₈N₈O₇S
Molecular Weight:748.904
Hs Code.:

(R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

Synonyms:(R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

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Chemical Property of (R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

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Technology Process of (R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

There total 4 articles about (R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869681-70-9
(R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester

: N₄-(2-(isopropylsulfonyl)phenyl)-N-(2-methoxy-5-methyl-4-(piperidin-4-yl)phenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine trifluoroacetate

: 1190115-60-6
(R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 2-methoxy-5-methyl-4-(piperidin-4-yl)aniline trifluoroacetate

: 1190115-60-6
(R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / isopropyl alcohol / 3 h / 150 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1190115-52-6
N-(2-(isopropylsulfonyl)phenyl)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine

: 1190115-60-6
(R)-tert-butyl 3-(4-(4-(4-(2-(isopropylsulfonyl)phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-ylamino)-5-methoxy-2-methylphenyl)piperidine-1-carbonyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / 1,2-dichloro-ethane / 0 - 20 °C

2: trifluoroacetic acid / isopropyl alcohol / 3 h / 150 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;