Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

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Chemical Name:Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester
CAS No.:190388-19-3
Molecular Formula:C₂₅H₃₄F₃N₃O₆
Molecular Weight:529.557
Hs Code.:

Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

Synonyms:Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

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Chemical Property of Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

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Technology Process of Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

There total 1 articles about Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2345-34-8
4-acetyloxy-benzoic acid

: (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-amide

: 190388-19-3
Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1021/jm960819g

Reference yield: 91.0%

: 190388-19-3
Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

: 190387-57-6
(3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

Guidance literature:: With Dess-Martin periodane; trifluoroacetic acid; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm960819g

Reference yield:

: 190388-19-3
Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

: (3RS)-(4-hydroxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, TFA / CH₂Cl₂ / 18 h / Ambient temperature

2: 62 percent / aq. K₂CO₃ / methanol / 18 h / Ambient temperature

With potassium carbonate; Dess-Martin periodane; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm960819g