(3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

Base Information

Chemical Name:(3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide
CAS No.:190387-57-6
Molecular Formula:C₂₅H₃₂F₃N₃O₆
Molecular Weight:527.541
Hs Code.:

Synonyms:(3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

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Chemical Property of (3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

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Technology Process of (3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

There total 3 articles about (3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 190388-19-3
Acetic acid 4-{(S)-2-methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-phenyl ester

: 190387-57-6
(3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

Guidance literature:: With Dess-Martin periodane; trifluoroacetic acid; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm960819g

Reference yield:

: 2345-34-8
4-acetyloxy-benzoic acid

: 190387-57-6
(3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 1-hydroxybenzotriazole monohydrate, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / tetrahydrofuran / 18 h / Ambient temperature

2: 91 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, TFA / CH₂Cl₂ / 18 h / Ambient temperature

With Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960819g

Reference yield:

: (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-amide

: 190387-57-6
(3RS)-(4-acetoxybenzoyl)-L-valyl-N-[3-(1,1,1-trifluoro-4-methyl-2-oxopentyl)]-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 1-hydroxybenzotriazole monohydrate, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / tetrahydrofuran / 18 h / Ambient temperature

2: 91 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, TFA / CH₂Cl₂ / 18 h / Ambient temperature

With Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960819g