4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid

Base Information

Chemical Name:4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid
CAS No.:1374785-43-9
Molecular Formula:C₂₃H₁₃Cl₃N₂O₄S
Molecular Weight:519.792
Hs Code.:

Synonyms:4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid

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Chemical Property of 4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid

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Technology Process of 4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid

There total 8 articles about 4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 21815-91-8
3-chlorobenzo[b]thiophen-2-carbonyl chloride

: 1374785-44-0
N-(4-chlorophenyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)terephthalamic acid methyl ester

: 1374785-43-9
4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 48h;

Reference yield:

: 55737-66-1
2-nitro-4-methoxycarbonylbenzoic acid

: 1374785-43-9
4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / pyridine / toluene / 4 h / Reflux

1.2: 14 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h

3.1: tetrahydrofuran / 3 h / 0 - 20 °C

4.1: sodium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C

With thionyl chloride; hydrogen; sodium hydroxide; pyridine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 610-29-7
2-nitroterephthalic acid

: 1374785-43-9
4-(4-chlorophenylcarbamoyl)-3-(3,6-dichlorobenzo[b]thiophene-2-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / methanol / 4 h / Reflux

1.2: pH 5 - 6

2.1: thionyl chloride / pyridine / toluene / 4 h / Reflux

2.2: 14 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 h

4.1: tetrahydrofuran / 3 h / 0 - 20 °C

5.1: sodium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C

With thionyl chloride; sulfuric acid; hydrogen; sodium hydroxide; pyridine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; toluene;