N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

Base Information

Chemical Name:N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide
CAS No.:127718-29-0
Molecular Formula:C₂₉H₄₉NO₇SSi₂
Molecular Weight:611.948
Hs Code.:

N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

Synonyms:N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

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Chemical Property of N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

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Technology Process of N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

There total 13 articles about N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 79172-00-2
N-(methanesulfonyl)-16-phenox-ω-tetranor-PGF_2α-carboxamide

: 996-50-9
N,N-diethyl-1,1,1-trimethylsilanamine

: 127718-29-0
N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

Guidance literature:: In acetone; at -45 ℃; for 1.5h;

Reference yield:

: 40665-68-7
dimethyl (3-phenoxy-2-oxopropyl)phosphonate

: 127718-29-0
N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / 5 h / 20 °C

2: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH₂Cl₂ / 0.5 h / -78 °C

3: 85 percent / pyridine / 2 h / 5 °C

4: 0.24 g / i-Bu₂AlH / CH₂Cl₂ / 1 h / -78 °C

5: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min

6: 90 percent / acetone / 1.5 h / -45 °C

With pyridine; hydrogenchloride; diisobutylaluminium hydride; diisobutyl(2,6-di-tert-butyl-4- methylphenoxy)aluminum; potassium carbonate; In dichloromethane; acetone;

Reference yield:

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

: 127718-29-0
N-{(Z)-7-[(1R,2R,3R,5S)-5-Hydroxy-2-((E)-(R)-4-phenoxy-3-trimethylsilanyloxy-but-1-enyl)-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoyl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / 1 h / 145 °C

2: CrO₃/pyridine, activated silica gel / CH₂Cl₂ / 0.42 h

3: KOH / CH₂Cl₂ / 0.33 h / Ambient temperature

4: 1 N hydrochloric acid / acetone / 0.17 h / 20 °C

5: 90 percent / aluminum diisobutyl-4-methyl-2,6-di-tert-butylphenoxide / CH₂Cl₂ / 0.5 h / -78 °C

6: 85 percent / pyridine / 2 h / 5 °C

7: 0.24 g / i-Bu₂AlH / CH₂Cl₂ / 1 h / -78 °C

8: 2.) 1 N hydrochloric acid / 1.) benzene, 20 deg C, 3 h, 2.) 10 min

9: 90 percent / acetone / 1.5 h / -45 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; potassium hydroxide; silica gel; diisobutylaluminium hydride; diisobutyl(2,6-di-tert-butyl-4- methylphenoxy)aluminum; In dichloromethane; acetone;