3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester

Base Information

Chemical Name:3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester
CAS No.:3496-13-7
Molecular Formula:C₂₀H₂₁NO₃
Molecular Weight:323.392
Hs Code.:

Synonyms:3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester

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Chemical Property of 3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester

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Technology Process of 3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester

There total 4 articles about 3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₁₉NO₃

: 74-88-4
methyl iodide

: 3496-13-7
3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester

Guidance literature:: C₁₉H₁₉NO₃; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 8h;
DOI:10.1016/j.tet.2015.10.039

Reference yield:

: 862907-10-6
tert-butyl 3-benzyl-2-oxoindoline-1-carboxylate

: 3496-13-7
3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutylammomium bromide; potassium carbonate / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

3.2: 8 h / 0 °C

With tetrabutylammomium bromide; sodium hydride; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; 1.1: |Michael Addition;
DOI:10.1016/j.tet.2015.10.039

Reference yield:

: tert-butyl 3-benzyl-3-(3-methoxy-3-oxopropyl)-2-oxoindoline-1-carboxylate

: 3496-13-7
3-(3-benzyl-1-methyl-2-oxo-2,3-dihydro-indol-3-yl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

2.2: 8 h / 0 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2015.10.039