1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

Base Information

Chemical Name:1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol
CAS No.:944389-43-9
Molecular Formula:C₂₆H₃₂O₇
Molecular Weight:456.536
Hs Code.:

Synonyms:1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

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Chemical Property of 1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

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Technology Process of 1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

There total 11 articles about 1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 944389-41-7
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-(2-(methoxymethoxy)phenyl)but-3-yn-2-ol

: 944389-43-9
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

Guidance literature:: With hydrogen; potassium hydrogencarbonate; palladium on activated charcoal; In ethyl acetate; at 20 ℃;
DOI:10.1016/j.tet.2007.02.033

Reference yield:

: 944389-28-0
4,8-dimethoxy-1-(methoxymethoxy)-2-(2-propen-1-yl)naphthalene

: 944389-43-9
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / osmium tetroxide; N-methylmorpholine-N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 24 h

2.1: 40 percent / sodium periodate / CH₂Cl₂; H₂O / 24 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

3.2: 67 percent / tetrahydrofuran / -78 - 20 °C

4.1: 91 percent / potassium bicarbonate; hydrogen / palladium on carbon / ethyl acetate / 20 °C

With sodium periodate; osmium(VIII) oxide; n-butyllithium; hydrogen; potassium hydrogencarbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone; tert-butyl alcohol;
DOI:10.1016/j.tet.2007.02.033

Reference yield:

: 944389-26-8
allyl 1,5-dimethoxynaphthalen-4-yl ether

: 944389-43-9
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / m-xylene / 19 h / 210 °C

2.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C

2.2: 92 percent / dimethylformamide / 1 h / 20 °C

3.1: 90 percent / osmium tetroxide; N-methylmorpholine-N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 24 h

4.1: 40 percent / sodium periodate / CH₂Cl₂; H₂O / 24 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

5.2: 67 percent / tetrahydrofuran / -78 - 20 °C

6.1: 91 percent / potassium bicarbonate; hydrogen / palladium on carbon / ethyl acetate / 20 °C

With sodium periodate; osmium(VIII) oxide; n-butyllithium; hydrogen; sodium hydride; potassium hydrogencarbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; m-xylene; acetone; tert-butyl alcohol; 1.1: Claisen rearrangement;
DOI:10.1016/j.tet.2007.02.033