1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one

Base Information

Chemical Name:1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one
CAS No.:944389-45-1
Molecular Formula:C₂₆H₃₀O₇
Molecular Weight:454.52
Hs Code.:

Synonyms:1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one

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Chemical Property of 1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one

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Technology Process of 1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one

There total 12 articles about 1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 944389-43-9
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-ol

: 944389-45-1
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one

Guidance literature:: With 4-methyl-morpholine; tetrapropylammonium perruthennate; 4 A molecular sieve; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tet.2007.02.033

Reference yield:

: 944389-27-9
4,8-dimethoxy-2-(2-propen-1-yl)naphthalen-1-ol

: 944389-45-1
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C

1.2: 92 percent / dimethylformamide / 1 h / 20 °C

2.1: 90 percent / osmium tetroxide; N-methylmorpholine-N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 24 h

3.1: 40 percent / sodium periodate / CH₂Cl₂; H₂O / 24 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

4.2: 67 percent / tetrahydrofuran / -78 - 20 °C

5.1: 91 percent / potassium bicarbonate; hydrogen / palladium on carbon / ethyl acetate / 20 °C

6.1: 60 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine; molecular sieves 4 Angstroem / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; sodium periodate; osmium(VIII) oxide; n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; sodium hydride; potassium hydrogencarbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1016/j.tet.2007.02.033

Reference yield:

: 944389-28-0
4,8-dimethoxy-1-(methoxymethoxy)-2-(2-propen-1-yl)naphthalene

: 944389-45-1
1-[4,8-dimethoxy-1-(methoxymethoxy)naphthalen-2-yl]-4-[(2-methoxymethoxy)phenyl]butan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / osmium tetroxide; N-methylmorpholine-N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 24 h

2.1: 40 percent / sodium periodate / CH₂Cl₂; H₂O / 24 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

3.2: 67 percent / tetrahydrofuran / -78 - 20 °C

4.1: 91 percent / potassium bicarbonate; hydrogen / palladium on carbon / ethyl acetate / 20 °C

5.1: 60 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine; molecular sieves 4 Angstroem / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; sodium periodate; osmium(VIII) oxide; n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; potassium hydrogencarbonate; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone; tert-butyl alcohol;
DOI:10.1016/j.tet.2007.02.033